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This was followed up by a 12-week open-label study of SRI augmentation with riluzole in similarly severely affected and refractory patients (Coric et al., 2005)

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6 mice/group was chosen as power calculation (using G*Power Version 3.1 59 ) at -level of 0.05 showed that it was sufficient for an 80% chance of detecting the published effect size of 2.02 for immunohistochemical measures of myelin and glia in the corpus callosum following cuprizone treatment 60